Real-world systems ranging from airline routes to cryptocurrency transfers are naturally modelled as dynamic graphs whose topology changes over time. Conventional benchmarks judge dynamic-graph learners by a handful of task-specific scores, yet seldom ask whether the embeddings themselves remain a truthful, interpretable reflection of the evolving network. W e formalize this requirement as representation integrity and derive a family of indexes that measure how closely embedding changes follow graph changes. Three synthetic scenarios--Gradual Merge, Abrupt Move, and Periodic Re-wiring--are used to screen forty-two candidate indexes. Based on which we recommend one index that passes all of our theoretical and empirical tests. In particular, this validated metric consistently ranks the provably stable UASE and IPP models highest. W e then use this index to do a comparative study on representation integrity of common dynamic graph learning models. This study exposes the scenario-specific strengths of neural methods, and shows a strong positive rank correlation with one-step link-prediction AUC. The proposed integrity framework, therefore, offers a task-agnostic and interpretable evaluation tool for dynamic-graph representation quality, providing more explicit guidance for model selection and future architecture design.

The rapid adoption of LLM-based conversational systems is already transforming the landscape of educational technology. However, the current state-of-the-art learning models do not take into account the student's affective states. Multiple studies in educational psychology support the claim that positive or negative emotional states can impact a student's learning capabilities. To bridge this gap, we present MathBuddy, an emotionally aware LLM-powered Math Tutor, which dynamically models the student's emotions and maps them to relevant pedagogical strategies, making the tutor-student conversation a more empathetic one. The student's emotions are captured from the conversational text as well as from their facial expressions. The student's emotions are aggregated from both modalities to confidently prompt our LLM Tutor for an emotionally-aware response. We have evaluated our model using automatic evaluation metrics across eight pedagogical dimensions and user studies. We report a massive 23 point performance gain using the win rate and a 3 point gain at an overall level using DAMR scores which strongly supports our hypothesis of improving LLM-based tutor's pedagogical abilities by modeling students' emotions. Our dataset and code are available at: https://github.com/ITU-NLP/MathBuddy .

Ensuring safety in human-robot interaction (HRI) is essential to foster user trust and enable the broader adoption of robotic systems. Traditional safety models primarily rely on sensor-based measures, such as relative distance and velocity, to assess physical safety. However, these models often fail to capture subjective safety perceptions, which are shaped by individual traits and contextual factors. In this paper, we introduce and analyze a parameterized general safety model that bridges the gap between physical and perceived safety by incorporating a personalization parameter, $ρ$, into the safety measurement framework to account for individual differences in safety perception. Through a series of hypothesis-driven human-subject studies in a simulated rescue scenario, we investigate how emotional state, trust, and robot behavior influence perceived safety. Our results show that $ρ$ effectively captures meaningful individual differences, driven by affective responses, trust in task consistency, and clustering into distinct user types. Specifically, our findings confirm that predictable and consistent robot behavior as well as the elicitation of positive emotional states, significantly enhance perceived safety. Moreover, responses cluster into a small number of user types, supporting adaptive personalization based on shared safety models. Notably, participant role significantly shapes safety perception, and repeated exposure reduces perceived safety for participants in the casualty role, emphasizing the impact of physical interaction and experiential change. These findings highlight the importance of adaptive, human-centered safety models that integrate both psychological and behavioral dimensions, offering a pathway toward more trustworthy and effective HRI in safety-critical domains.

Species Distribution Models (SDMs) often suffer from spatial autocorrelation (SAC), leading to biased performance estimates. We tested cross-validation (CV) strategies - random splits, spatial blocking with varied distances, environmental (ENV) clustering, and a novel spatio-temporal method - under two proposed training schemes: LAST FOLD, widely used in spatial CV at the cost of data loss, and RETRAIN, which maximizes data usage but risks reintroducing SAC. LAST FOLD consistently yielded lower errors and stronger correlations. Spatial blocking at an optimal distance (SP 422) and ENV performed best, achieving Spearman and Pearson correlations of 0.485 and 0.548, respectively, although ENV may be unsuitable for long-term forecasts involving major environmental shifts. A spatio-temporal approach yielded modest benefits in our moderately variable dataset, but may excel with stronger temporal changes. These findings highlight the need to align CV approaches with the spatial and temporal structure of SDM data, ensuring rigorous validation and reliable predictive outcomes.

The correlation between NLG automatic evaluation metrics and human evaluation is often regarded as a critical criterion for assessing the capability of an evaluation metric. However, different grouping methods and correlation coefficients result in various types of correlation measures used in meta-evaluation. In specific evaluation scenarios, prior work often directly follows conventional measure settings, but the characteristics and differences between these measures have not gotten sufficient attention. Therefore, this paper analyzes 12 common correlation measures using a large amount of real-world data from six widely-used NLG evaluation datasets and 32 evaluation metrics, revealing that different measures indeed impact the meta-evaluation results. Furthermore, we propose three perspectives that reflect the capability of meta-evaluation and find that the measure using global grouping and Pearson correlation exhibits the best overall performance, involving the discriminative power, ranking consistency, and sensitivity to score granularity.

Developing therapeutics is a lengthy and expensive process that requires the satisfaction of many different criteria, and AI models capable of expediting the process would be invaluable. However, the majority of current AI approaches address only a narrowly defined set of tasks, often circumscribed within a particular domain. To bridge this gap, we introduce Tx-LLM, a generalist large language model (LLM) fine-tuned from PaLM-2 which encodes knowledge about diverse therapeutic modalities. Tx-LLM is trained using a collection of 709 datasets that target 66 tasks spanning various stages of the drug discovery pipeline. Using a single set of weights, Tx-LLM simultaneously processes a wide variety of chemical or biological entities(small molecules, proteins, nucleic acids, cell lines, diseases) interleaved with free-text, allowing it to predict a broad range of associated properties, achieving competitive with state-of-the-art (SOTA) performance on 43 out of 66 tasks and exceeding SOTA on 22. Among these, Tx-LLM is particularly powerful and exceeds best-in-class performance on average for tasks combining molecular SMILES representations with text such as cell line names or disease names, likely due to context learned during pretraining. We observe evidence of positive transfer between tasks with diverse drug types (e.g.,tasks involving small molecules and tasks involving proteins), and we study the impact of model size, domain finetuning, and prompting strategies on performance. We believe Tx-LLM represents an important step towards LLMs encoding biochemical knowledge and could have a future role as an end-to-end tool across the drug discovery development pipeline.

Background and objective Risk prediction models aim at identifying people at higher risk of developing a target disease. Feature selection is particularly important to improve the prediction model performance avoiding overfitting and to identify the leading cancer risk (and protective) factors. Assessing the stability of feature selection/ranking algorithms becomes an important issue when the aim is to analyze the features with more prediction power. Methods This work is focused on colorectal cancer, assessing several feature ranking algorithms in terms of performance for a set of risk prediction models (Neural Networks, Support Vector Machines (SVM), Logistic Regression, k-Nearest Neighbors and Boosted Trees). Additionally, their robustness is evaluated following a conventional approach with scalar stability metrics and a visual approach proposed in this work to study both similarity among feature ranking techniques as well as their individual stability. A comparative analysis is carried out between the most relevant features found out in this study and features provided by the experts according to the state-of-the-art knowledge. Results The two best performance results in terms of Area Under the ROC Curve (AUC) are achieved with a SVM classifier using the top-41 features selected by the SVM wrapper approach (AUC=0.693) and Logistic Regression with the top-40 features selected by the Pearson (AUC=0.689). Experiments showed that performing feature selection contributes to classification performance with a 3.9% and 1.9% improvement in AUC for the SVM and Logistic Regression classifier, respectively, with respect to the results using the full feature set. The visual approach proposed in this work allows to see that the Neural Network-based wrapper ranking is the most unstable while the Random Forest is the most stable.

Measuring conditional dependence is an important topic in statistics with broad applications including graphical models. Under a factor model setting, a new conditional dependence measure based on projection is proposed. The corresponding conditional independence test is developed with the asymptotic null distribution unveiled where the number of factors could be high-dimensional. It is also shown that the new test has control over the asymptotic significance level and can be calculated efficiently. A generic method for building dependency graphs without Gaussian assumption using the new test is elaborated. Numerical results and real data analysis show the superiority of the new method.